What determines where bone remodeling will occur?
Bone remodeling is regulated by a variety of systemic hormones and by local regulatory factors (Table 2) that affect cells of the osteoclast and osteoblast lineage and exert their effects on: (1) the replication of undifferentiated cell; (2) the recruitment of cells; and (3) the differentiated function of cells.
Why does bone remodeling occur in an adult skeleton?
Bone remodeling serves to adjust bone architecture to meet changing mechanical needs and it helps to repair microdamages in bone matrix preventing the accumulation of old bone. It also plays an important role in maintaining plasma calcium homeostasis. The regulation of bone remodeling is both systemic and local.
Where does bone remodeling occur in an adult skeleton?
Bone remodeling takes place in what Frost termed the Basic Multicellular Unit (BMU), which comprises the osteoclasts, osteoblasts, and osteocytes within the bone-remodeling cavity (Fig. 1). In cancellous bone remodeling occurs on the surface of trabeculae and lasts about 200 days in normal bone.
Why does bone remodeling occur in an adult skeleton quizlet?
It results from mechanical stress and remodeling. -Bones develop their specific features according to the stresses placed on them as they grow and fit together, and as they are pulled on by muscles.
What factors influence bone remodeling even after adulthood?
In addition to the well-known parathyroid hormone, calcitonin, thyroid hormones, growth hormone, and sexual steroids, other hormones, cytokines, and growth factors with endocrine, paracrine, and autocrine actions play an important role in bone remodeling (45).